The current release (R24 - December 2011) contains the updated annotation of the genome sequence of M. tuberculosis H37Rv. In total, 2298 genes have been updated with information from the current literature on regulation, function, proteomics, operon structure, and mutants. Some of the notable changes in this release are:
One new gene has been annotated - Rv0691A, mycofactocin precursor protein
18 genes have been updated with characterization of mutant strains
Links to 151 protein structures in the Protein data Bank have been added. The structures of 44 proteins are reported for the first time.
Results from the publication by de Souza et al., 2011 have been added. This provides proteomic evidence for 2163 proteins, of which 387 did not previously have proteomic annotation in TubercuList.
TubercuList in numbers:
4,411,532 bp of DNA sequence representing the whole Mycobacterium tuberculosis chromosome (strain H37Rv, EMBL/GenBank/DDBJ entry AL123456)
The TubercuList knowledge base integrates genome details, protein information, drug and transcriptome data, mutant and operon annotation, bibliography, structural views and comparative genomics, in a structured manner required for the rational development of new diagnostic, therapeutic and prophylactic measures against tuberculosis. With the means of expert curation and continuous updates, we deliver a broad view of the Mycobacterium tuberculosis genome.
The TubercuList database and website has been created by and is currently being annotated and maintained in the laboratory of Professor Stewart Cole, part of the Global Health Institute at the Ecole Polytechnique Fédérale de Lausanne. TubercuList is supported by the Swiss Institute of Bioinformatics.
Submission form for available TB knockouts/mutants
If you have a TB knockout/mutant that you would like to share, please fill out the following form with as much information as you can provide. See a compiled list of all available data here or on the corresponding Gene Pages.
