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Gene: rodA

General annotation | Coordinates | Sequence | Genome Browser | Structural information | Orthologs/Cross-references | Interacting Drugs/Compounds | Bibliography


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General annotation
Gene namerodA
Rv numberRv0017c
Synonym(s)ftsW
TypeCDS
FunctionTHIS IS A SEPTUM-PEPTIDOGLYCAN BIOSYNTHETIC PROTEIN, INVOLVED IN CELL WALL FORMATION. PLAYS A ROLE IN THE STABILIZATION OF THE FTSZ RING DURING CELL DIVISION.
ProductPROBABLE CELL DIVISION PROTEIN RODA
CommentsRv0017c, (MTCY10H4.17c), len: 469 aa. Probable rodA (alternate gene name: ftsW), cell division protein, integral membrane protein, equivalent to MLCB1770_12|T10012 probable cell division protein from Mycobacterium leprae (465 aa), FASTA scores: opt: 2475, E(): 0, (81.9% identity in 469 aa overlap). Also highly similar to others e.g. T36715|SCH69.16 from Streptomyces coelicolor (479 aa); NP_243432.1|NC_002570 from Bacillus halodurans (366 aa); NP_347145.1|NC_003030 from Clostridium acetobutylicum (400 aa); etc. Also similar to MTCY270_14 from Mycobacterium tuberculosis FASTA score: (32.2% identity in 369 aa overlap). BELONGS TO THE FTSW/RODA/SPOVE FAMILY.
Molecular mass (Da)50610.7
Isoelectric point10.1153
Gene length (bp)1410
Protein length469
Location (kb)21.64


Functional categorycell wall and cell processes


Mutationnon essential gene by Himar1-based transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Required for survival in primary murine macrophages, by transposon site hybridization (TraSH) in H37Rv (See Rengarajan et al., 2005). mutants available at TARGET website


Coordinates
TypeStartEndOrientation
CDS2023121640-


Protein sequence in FASTA format
>M. tuberculosis H37Rv | rodA
MTTRLQAPVAVTPPLPTRRNAELLLLCFAAVITFAALLVVQANQDQGVPWDLTSYGLAFLTLFGSAHLAIRRFAPYTDPL
LLPVVALLNGLGLVMIHRLDLVDNEIGEHRHPSANQQMLWTLVGVAAFALVVTFLKDHRQLARYGYICGLAGLVFLAVPA
LLPAALSEQNGAKIWIRLPGFSIQPAEFSKILLLIFFSAVLVAKRGLFTSAGKHLLGMTLPRPRDLAPLLAAWVISVGVM
VFEKDLGASLLLYTSFLVVVYLATQRFSWVVIGLTLFAAGTLVAYFIFEHVRLRVQTWLDPFADPDGTGYQIVQSLFSFA
TGGIFGTGLGNGQPDTVPAASTDFIIAAFGEELGLVGLTAILMLYTIVIIRGLRTAIATRDSFGKLLAAGLSSTLAIQLF
IVVGGVTRLIPLTGLTTPWMSYGGSSLLANYILLAILARISHGARRPLRTRPRNKSPITAAGTEVIERV
Blastp: results
TransMembrane prediction using Hidden Markov Models: tmhmm
Microbe Genome Browser
Genomic sequence

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Structural information
Protein Data BankNo structure available
PFAMProtein Family Domains


Orthologs/Cross-references
CDC1551MT0020
Gene Ontologyplasma membrane
cell wall organization
cell cycle
regulation of cell shape
peptidoglycan biosynthetic process
integral to membrane
cell division
MbovisMb0017c
MlepraeML0019
MmarinumMMAR_0019
MsmegmatisMSMEG_0032
UniProtP63760


Interacting Drugs/Compounds
TDR TargetsRv0017c


Expression Data
TBDBRv0017c


Bibliography
Sassetti CM, Boyd DH, Rubin EJ,
Genes required for mycobacterial growth defined by high density mutagenesis.
Mol Microbiol (2003) 48(1):77-84
Rengarajan J, Bloom BR, Rubin EJ,
Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages.
Proc Natl Acad Sci U S A (2005) 102:8327