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Gene: Rv2417c

General annotation | Coordinates | Sequence | Genome Browser | Structural information | Orthologs/Cross-references | Interacting Drugs/Compounds | Bibliography


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General annotation
Gene nameRv2417c
Rv numberRv2417c
TypeCDS
FunctionFUNCTION UNKNOWN
ProductCONSERVED HYPOTHETICAL PROTEIN
CommentsRv2417c, (MTCY253.03), len: 280 aa. Conserved hypothetical protein, highly similar to Q9RDL7|SCC123.07c HYPOTHETICAL 29.2 KDA PROTEIN from Streptomyces coelicolor (281 aa), FASTA scores: opt: 579, E(): 3.6e-27, (38.3% identity in 274 aa overlap). Also some similarity with DEGV proteins or hypothetical proteins from other organisms, e.g. Q9RSY3|DR1986 from Deinococcus radiodurans (281 aa), FASTA scores: opt: 393, E(): 3.4e-16, (31.0% identity in 280 aa overlap); P32436|DEGV_BACSU from Bacillus subtilis (281 aa), FASTA scores: opt: 365, E(): 1.5e-14, (27.8% identity in 284 aa overlap); BAB41937|BAB46307|SA0704|SAV0749 Conserved hypothetical protein from Staphylococcus aureus strain Mu50 and N315 (288 aa), FASTA scores: opt: 371, E(): 7e-15, (28.85% identity in 281 aa overlap); etc.
Molecular mass (Da)28455.6
Isoelectric point6.5076
Gene length (bp)843
Protein length280
Location (kb)2716.31


Functional categoryconserved hypotheticals


ProteomicsIdentified in the cell membrane fraction of M. tuberculosis H37Rv using 2DLC/MS (See Mawuenyega et al., 2005).
Mutationnon essential gene by Himar1-based transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003) mutants available at TARGET website


Coordinates
TypeStartEndOrientation
CDS27154722716314-


Protein sequence in FASTA format
>M. tuberculosis H37Rv | Rv2417c
MTVVVVTDTSCRLPADLREQWSIRQVPLHILLDGLDLRDGVDEIPDDIHKRHATTAGATPVELSAAYQRALADSGGDGVV
AVHISSALSGTFRAAELTAAELGPAVRVIDSRSAAMGVGFAALAAGRAAAAGDELDTVARAAAAAVSRIHAFVAVARLDN
LRRSGRISGAKAWLGTALALKPLLSVDDGKLVLVQRVRTVSNATAVMIDRVCQLVGDRPAALAVHHVADPAAANDVAAAL
AERLPACEPAMVTAMGPVLALHVGAGAVGVCVDVGASPPA
Blastp: results
TransMembrane prediction using Hidden Markov Models: tmhmm
Microbe Genome Browser
Genomic sequence

Add extra bases upstream (5') and downstream (3')



Structural information
Protein Data BankNo structure available
PFAMProtein Family Domains


Orthologs/Cross-references
CDC1551MT2490
MbovisMb2440c
MlepraeML1451
MmarinumMMAR_3745
MsmegmatisMSMEG_4577
UniProtP67368


Interacting Drugs/Compounds
TDR TargetsRv2417c


Expression Data
TBDBRv2417c


Bibliography
Sassetti CM, Boyd DH, Rubin EJ,
Genes required for mycobacterial growth defined by high density mutagenesis.
Mol Microbiol (2003) 48(1):77-84
Mawuenyega KG, Forst CV, Dobos KM, Belisle JT, Chen J, Bradbury EM, Bradbury AR, Chen X,
Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling.
Mol Biol Cell (2005) 16(1):396-404