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Gene: Rv2258c

General annotation | Coordinates | Sequence | Genome Browser | Structural information | Orthologs/Cross-references | Interacting Drugs/Compounds | Bibliography


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General annotation
Gene nameRv2258c
Rv numberRv2258c
TypeCDS
FunctionPossibly involved in transcriptional regulation
ProductPossible transcriptional regulatory protein
CommentsRv2258c, (MTV022.08c), len: 353 aa. Possible transcriptional regulatory protein, similar to several hypothetical proteins from C. elegans. FASTA scores: sptr|O01593|O01593 CODED FOR BY C. ELEGANS CDNA YK102 F (365 aa) opt: 577, E(): 6.4e-31; (30.5% identity in 341 aa overlap). Contains possible helix-turn helix motif at aa 47-68 (+3.65 SD)
Molecular mass (Da)37513.5
Isoelectric point4.3523
Gene length (bp)1062
Protein length353
Location (kb)2531.9


Functional categoryregulatory proteins


ProteomicsIdentified in the membrane fraction of M. tuberculosis H37Rv using 1D-SDS-PAGE and uLC-MS/MS (See Gu et al., 2003).
Mutationnon essential gene by Himar1-based transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003) mutants available at TARGET website


Coordinates
TypeStartEndOrientation
CDS25308362531897-
RBS25319072531913-


Protein sequence in FASTA format
>M. tuberculosis H37Rv | Rv2258c
MSGALETTEEFGNRFVAAIDSAGLAILVSVGHQTGLLDTMAGLPPATSMEIAEAAGLEERYVREWLGGMTTGQIVEYDAG
SSTYSLPAHRAGMLTRAAGPDNLAVIAQFVSLLGEVEQKVIRCFREGGGVPYSEYPRFHKLMAEMSGMVFDAALIDVVLP
LVDGLPDRLRSGADVADFGCGSGRAVKLMAQAFGASRFTGIDFSDEAVAAGTEEAARLGLANATFERHDLAELDKVGAYD
VITVFDAIHDQAQPARVLQNIYRALRPGGVLLMVDIKASSQLEDNVGVPLSTYLYTTSLMHCMTVSLALDGAGLGTVWGR
QLATSMLADAGFTDVTVAEIESDVLNNYYIARK
Blastp: results
TransMembrane prediction using Hidden Markov Models: tmhmm
Microbe Genome Browser
Genomic sequence

Add extra bases upstream (5') and downstream (3')



Structural information
Protein Data BankNo structure available
PFAMProtein Family Domains


Orthologs/Cross-references
CDC1551MT2319
Gene Ontologymetabolic process
methyltransferase activity
MbovisMb2282c
MlepraeML1783
MmarinumMMAR_3349
MsmegmatisMSMEG_4338
UniProtO53532


Interacting Drugs/Compounds
TDR TargetsRv2258c


Expression Data
TBDBRv2258c


Bibliography
Sassetti CM, Boyd DH, Rubin EJ,
Genes required for mycobacterial growth defined by high density mutagenesis.
Mol Microbiol (2003) 48(1):77-84
Gu S, Chen J, Dobos KM, Bradbury EM, Belisle JT, Chen X,
Comprehensive proteomic profiling of the membrane constituents of a Mycobacterium tuberculosis strain.
Mol Cell Proteomics (2003) 2(12):1284-96