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Search term: Rv0500B

General annotation | Coordinates | Sequence | Structural information | Orthologs/Cross-references | Interacting Drugs/Compounds | Bibliography
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General annotation
Gene nameRv0500B
Rv numberRv0500B
TypeCDS
FunctionFunction unknown
ProductConserved hypothetical protein
CommentsRv0500B, len: 33 aa. Conserved hypothetical protein. Basic protein 18 of the 33 aa are Arg or Lys, with strong similarity to AL079345|SCE68_25 protein from Streptomyces coelicolor cosmid E6 (32 aa), FASTA scores: opt: 176, E(): 1e-06, (93.1% identity in 29 aa overlap). Same gene arrangement in both actinomycetes.
Molecular mass (Da)4145.19
Isoelectric point13.4138
Gene length (bp)102
Protein length33
Location (kb)591.475


Functional categoryconserved hypotheticals
Prediction based on GO and InterPro: intermediary metabolism and respiration (See Mazandu and Mulder, 2012)


MutationNon-essential gene for in vitro growth of H37Rv, by sequencing of Himar1-based transposon mutagenesis (See Griffin et al., 2011). Check for mutants available at TARGET website


Coordinates
TypeStartEndOrientation
CDS591475591576+


Protein sequence in FASTA format
>M. tuberculosis H37Rv|Rv0500B|Rv0500B
MGSVIKKRRKRMSKKKHRKLLRRTRVQRRKLGK
Blastp: Pre-computed results
TransMembrane prediction using Hidden Markov Models: TMHMM
Genomic sequence

Add extra bases upstream (5') and downstream (3')



Structural information
Protein Data BankNo structure available
PFAMP0A5C9


Orthologs/Cross-references
M. lepraeML2428A
UniProtP0A5C9
Multiple Sequences Alignment: between orthologs


Interacting Drugs/Compounds
TDR TargetsRv0500B


Expression Data
TBDBRv0500B


Bibliography
Griffin JE, Gawronski JD, Dejesus MA, Ioerger TR, Akerley BJ, Sassetti CM,
High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism.
PLoS Pathog (2011) 7(9):e1002251
Cited for: Mutant
Mazandu GK, Mulder NJ,
Function Prediction and Analysis of Mycobacterium tuberculosis Hypothetical Proteins.
Int J Mol Sci (2012) 13(6):7283-302
Cited for: Function