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Gene: Rv0038

General annotation | Coordinates | Sequence | Genome Browser | Structural information | Orthologs/Cross-references | Interacting Drugs/Compounds | Bibliography


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General annotation
Gene nameRv0038
Rv numberRv0038
TypeCDS
FunctionFUNCTION UNKNOWN
ProductCONSERVED HYPOTHETICAL PROTEIN
CommentsRv0038, (MTCY10H4.38), len: 202 aa. Conserved hypothetical protein, equivalent to MLCB1770_16|Q50191|Y038_MYCLE hypothetical 22.0 kDa from Mycobacterium leprae (202 aa), FASTA scores: opt: 1194, E(): 0, (88.6% identity in 202 aa overlap). Also highly similar or similar to other hypothetical proteins e.g. CAB72194.1|AL138851|SCE59.07c from Streptomyces coelicolor (193 aa); AAC06288.1|AF050466 from Mycobacterium bovis (82 aa) (similarity in N-terminus); NP_224347.1|NC_000922|YqgE from Chlamydophila pneumoniae (188 aa); YQGE_ECOLI HYPOTHETICAL 20.7 kDa PROTEIN (187 aa), FASTA score: (29.5% identity in 166 aa overlap); etc.
Molecular mass (Da)21776
Isoelectric point5.2732
Gene length (bp)609
Protein length202
Location (kb)41.304


Functional categoryconserved hypotheticals


ProteomicsIdentified in the membrane fraction of M. tuberculosis H37Rv using 1D-SDS-PAGE and uLC-MS/MS (See Gu et al., 2003).
Mutationnon essential gene by Himar1-based transposon mutagenesis in H37Rv and CDC1551 strains (see Sassetti et al., 2003 and Lamichhane et al., 2003) mutants available at TARGET website
Annotation Changesproteomics updated on 01-APR-2009


Coordinates
TypeStartEndOrientation
CDS4130441912+


Protein sequence in FASTA format
>M. tuberculosis H37Rv | Rv0038
MVAPHEDPEDHVAPAAQRVRAGTLLLANTDLLEPTFRRSVIYIVEHNDGGTLGVVLNRPSETAVYNVLPQWAKLAAKPKT
MFIGGPVKRDAALCLAVLRVGADPEGVPGLRHVAGRLVMVDLDADPEVLAAAVEGVRIYAGYSGWTIGQLEGEIERDDWI
VLSALPSDVLVGPRADLWGQVLRRQPLPLSLLATHPIDLSRN
Blastp: results
TransMembrane prediction using Hidden Markov Models: tmhmm
Microbe Genome Browser
Genomic sequence

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Structural information
Protein Data BankNo structure available
PFAMProtein Family Domains


Orthologs/Cross-references
CDC1551MT0043
MbovisMb0039
MlepraeML0028
MsmegmatisMSMEG_6921
UniProtP67757


Interacting Drugs/Compounds
TDR TargetsRv0038


Bibliography
Sassetti CM, Boyd DH, Rubin EJ,
Genes required for mycobacterial growth defined by high density mutagenesis.
Mol Microbiol (2003) 48(1):77-84
Lamichhane G, Zignol M, Blades NJ, Geiman DE, Dougherty A, Grosset J, Broman KW, Bishai WR,
A postgenomic method for predicting essential genes at subsaturation levels of mutagenesis: application to Mycobacterium tuberculosis.
Proc Natl Acad Sci U S A (2003) 100 :7213
Gu S, Chen J, Dobos KM, Bradbury EM, Belisle JT, Chen X,
Comprehensive proteomic profiling of the membrane constituents of a Mycobacterium tuberculosis strain.
Mol Cell Proteomics (2003) 2(12):1284-96