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Gene: Rv0025

General annotation | Coordinates | Sequence | Genome Browser | Structural information | Orthologs/Cross-references | Interacting Drugs/Compounds | Bibliography


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General annotation
Gene nameRv0025
Rv numberRv0025
TypeCDS
FunctionFUNCTION UNKNOWN
ProductCONSERVED HYPOTHETICAL PROTEIN
CommentsRv0025, (MTCY10H4.25), len: 120 aa. Conserved hypothetical protein, showing some similarity to other proteins from Mycobacterium tuberculosis e.g. Rv0739 (268 aa), FASTA score: (37.6% identity in 101 aa overlap), and Rv0026 FASTA score: (35.4% identity in 113 aa overlap); etc.
Molecular mass (Da)13099.8
Isoelectric point5.6891
Gene length (bp)363
Protein length120
Location (kb)29.245


Functional categoryconserved hypotheticals


Mutationnon essential gene by Himar1-based transposon mutagenesis in H37Rv and CDC1551 strains (see Sassetti et al., 2003 and Lamichhane et al., 2003) mutants available at TARGET website


Coordinates
TypeStartEndOrientation
CDS2924529607+


Protein sequence in FASTA format
>M. tuberculosis H37Rv | Rv0025
MSEQAGSSVAVIQERQALLARQHDAVAEADRELADVLASAHAAMRESVRRLDAIAAELDRAVPDQDQLAVDTPMGAREFQ
TFLVAKQREIVAVVAAAHELDRAKSAVLKRLRAQYTEPAR
Blastp: results
TransMembrane prediction using Hidden Markov Models: tmhmm
Microbe Genome Browser
Genomic sequence

Add extra bases upstream (5') and downstream (3')



Structural information
Protein Data BankNo structure available
PFAMProtein Family Domains


Orthologs/Cross-references
CDC1551MT0028
MbovisMb0026
MmarinumMMAR_0044
UniProtP71595


Interacting Drugs/Compounds
TDR TargetsRv0025


Expression Data
TBDBRv0025


Bibliography
Sassetti CM, Boyd DH, Rubin EJ,
Genes required for mycobacterial growth defined by high density mutagenesis.
Mol Microbiol (2003) 48(1):77-84
Lamichhane G, Zignol M, Blades NJ, Geiman DE, Dougherty A, Grosset J, Broman KW, Bishai WR,
A postgenomic method for predicting essential genes at subsaturation levels of mutagenesis: application to Mycobacterium tuberculosis.
Proc Natl Acad Sci U S A (2003) 100 :7213