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Gene: Rv0007

General annotation | Coordinates | Sequence | Genome Browser | Structural information | Orthologs/Cross-references | Interacting Drugs/Compounds | Bibliography


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General annotation
Gene nameRv0007
Rv numberRv0007
TypeCDS
FunctionUNKNOWN
ProductPOSSIBLE CONSERVED MEMBRANE PROTEIN
Evidenceexperimental
CommentsRv0007, (MTCY10H4.05), len: 304 aa. Possible conserved membrane protein, highly similar to Z70722|MLCB1770_7 from Mycobacterium leprae (303 aa), FASTA scores: opt: 812, E(): 1.6e-25, (54.2% identity in 319 aa overlap). C-terminal part highly similar to C-terminus of CAB92992.1|AL357152 putative integral membrane protein from Streptomyces coelicolor (185 aa); and N-terminal part highly similar to C-terminus of NP_302684.1|NC_002677 hypothetical protein from Mycobacterium leprae (123 aa). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
Molecular mass (Da)31040.8
Isoelectric point9.1696
Gene length (bp)915
Protein length304
Location (kb)9.914


Functional categorycell wall and cell processes


ProteomicsIdentified in the membrane fraction of M. tuberculosis H37Rv using nanoLC-MS/MS; predicted integral membrane protein (See Xiong et al., 2005).
TranscriptomemRNA identified by microarray analysis and down-regulated after 4h, 24h and 96h of starvation (see Betts et al., 2002).
Annotation Changesproteomics updated on 01-APR-2009


Coordinates
TypeStartEndOrientation
CDS991410828+


Protein sequence in FASTA format
>M. tuberculosis H37Rv | Rv0007
MTAPNEPGALSKGDGPNADGLVDRGGAHRAATGPGRIPDAGDPPPWQRAATRQSQAGHRQPPPVSHPEGRPTNPPAAADA
RLNRFISGASAPVTGPAAAVRTPQPDPDASLGCGDGSPAEAYASELPDLSGPTPRAPQRNPAPARPAEGGAGSRGDSAAG
SSGGRSITAESRDARVQLSARRSRGPVRASMQIRRIDPWSTLKVSLLLSVALFFVWMITVAFLYLVLGGMGVWAKLNSNV
GDLLNNASGSSAELVSSGTIFGGAFLIGLVNIVLMTALATIGAFVYNLITDLIGGIEVTLADRD
Blastp: results
TransMembrane prediction using Hidden Markov Models: tmhmm
Microbe Genome Browser
Genomic sequence

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Orthologs/Cross-references
CDC1551MT0007
Gene Ontologyplasma membrane
integral to membrane
MbovisMb0007
MlepraeML0007
MsmegmatisMSMEG_0007
UniProtP71575


Interacting Drugs/Compounds
TDR TargetsRv0007


Bibliography
Betts JC, Lukey PT, Robb LC, McAdam RA, Duncan K,
Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling
Mol Microbiol (2002) 43 :717
Marmiesse M, Brodin P, Buchrieser C, Gutierrez C, Simoes N, Vincent V, Glaser P, Cole ST, Brosch R,
Macro-array and bioinformatic analyses reveal mycobacterial 'core' genes, variation in the ESAT-6 gene family and new phylogenetic markers for the Mycobacterium tuberculosis complex.
Microbiology (2004) 150 (Pt 2):483-96
Xiong Y, Chalmers MJ, Gao FP, Cross TA, Marshall AG,
Identification of Mycobacterium tuberculosis H37Rv integral membrane proteins by one-dimensional gel electrophoresis and liquid chromatography electrospray ionization tandem mass spectrometry.
J Proteome Res (2005) 4:855